Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1( R )-4-(trifluoromethyl)phenyl}ethyl-3( S )-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Selective, and Orally Bioavailable CCR5 Antagonist
Tagat, Jayaram R., McCombie, Stuart W., Nazareno, Dennis, Labroli, Marc A., Xiao, Yushi, Steensma, Ruo W., Strizki, Julie M., Baroudy, Bahige M., Cox, Kathleen, Lachowicz, Jean, Varty, Geoffrey, WatkiТом:
47
Мова:
english
Журнал:
Journal of Medicinal Chemistry
DOI:
10.1021/jm0304515
Date:
May, 2004
Файл:
PDF, 78 KB
english, 2004
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