Пожертвування 15 вересня 2024 – 1 жовтня 2024 Про збір коштів

Volume 21; Issue 23

Bioorganic & Medicinal Chemistry

Volume 21; Issue 23

1

Small molecule fusion inhibitors: Design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41

He, Xiao-Yang, Lu, Lu, Qiu, Jiayin, Zou, Peng, Yu, Fei, Jiang, Xing-Kai, Li, Lin, Jiang, Shibo, Liu, Shuwen, Xie, Lan

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 321 KB

english, 2013

2

Design of fluorinated 5-HT4R antagonists: Influence of the basicity and lipophilicity toward the 5-HT4R binding affinities

Fontenelle, Clement Q., Wang, Zhong, Fossey, Christine, Cailly, Thomas, Linclau, Bruno, Fabis, Frederic

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 828 KB

english, 2013

3

Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA)

Jiang, Yongying, Hu, Longqin

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 541 KB

english, 2013

4

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53

Abdel-Halim, Mohammad, Keeton, Adam B., Gurpinar, Evrim, Gary, Bernard D., Vogel, Simon M., Engel, Matthias, Piazza, Gary A., Boeckler, Frank M., Hartmann, Rolf W., Abadi, Ashraf H.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 994 KB

english, 2013

5

Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases

Casuscelli, Francesco, Ardini, Elena, Avanzi, Nilla, Casale, Elena, Cervi, Giovanni, D’Anello, Matteo, Donati, Daniele, Faiardi, Daniela, Ferguson, Ronald D., Fogliatto, Gianpaolo, Galvani, Arturo, Ma

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.50 MB

english, 2013

6

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

Koch, Pierre, Akkari, Rhalid, Brunschweiger, Andreas, Borrmann, Thomas, Schlenk, Miriam, Küppers, Petra, Köse, Meryem, Radjainia, Hamid, Hockemeyer, Jörg, Drabczyńska, Anna, Kieć-Kononowicz, Katarzyna

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1012 KB

english, 2013

7

Design and evaluation of xanthine based adenosine receptor antagonists: Potential hypoxia targeted immunotherapies

Thomas, Rhiannon, Lee, Joslynn, Chevalier, Vincent, Sadler, Sara, Selesniemi, Kaisa, Hatfield, Stephen, Sitkovsky, Michail, Ondrechen, Mary Jo, Jones, Graham B.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 2.81 MB

english, 2013

8

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs

Rai, Diwakar, Chen, Wenmin, Tian, Ye, Chen, Xuwang, Zhan, Peng, De Clercq, Erik, Pannecouque, Christophe, Balzarini, Jan, Liu, Xinyong

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 757 KB

english, 2013

9

Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity

Torijano-Gutiérrez, Sandra, Díaz-Oltra, Santiago, Falomir, Eva, Murga, Juan, Carda, Miguel, Marco, J. Alberto

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.51 MB

english, 2013

10

The effect of pyridyl substituents on the thermodynamics of porphyrin binding to G-quadruplex DNA

Rowland, Gerald B., Barnett, Kerry, DuPont, Jesse I., Akurathi, Gopalakrishna, Le, Vu H., Lewis, Edwin A.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.23 MB

english, 2013

11

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

Amewu, Richard K., Chadwick, James, Hussain, Afthab, Panda, Somnath, Rinki, Rinki, Janneh, Omar, Ward, Stephen A., Miguel, Candel, Burrell-Saward, Hollie, Vivas, Livia, O’Neill, Paul M.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.81 MB

english, 2013

12

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: The influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents

Eibl, Christoph, Tomassoli, Isabelle, Munoz, Lenka, Stokes, Clare, Papke, Roger L., Gündisch, Daniela

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.22 MB

english, 2013

13

17(E)-Picolinylidene androstane derivatives as potential inhibitors of prostate cancer cell growth: Antiproliferative activity and molecular docking studies

Ajduković, Jovana J., Djurendić, Evgenija A., Petri, Edward T., Klisurić, Olivera R., Ćelić, Andjelka S., Sakač, Marija N., Jakimov, Dimitar S., Gaši, Katarina M. Penov

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 2.10 MB

english, 2013

14

Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes

Wang, Jiang, Feng, Ying, Ji, Xun, Deng, Guanghui, Leng, Ying, Liu, Hong

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 975 KB

english, 2013

15

3,5-Bis(benzylidene)-4-piperidones and related N-acyl analogs: A novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum

Das, Umashankar, Singh, Ravi S.P., Alcorn, Jane, Hickman, Mark R., Sciotti, Richard J., Leed, Susan E., Lee, Patricia J., Roncal, Norma, Dimmock, Jonathan R.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 806 KB

english, 2013

16

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease

Dewdney, Tamaria G., Wang, Yong, Liu, Zhigang, Sharma, Shiv K., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.12 MB

english, 2013

17

Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents

Luo, Wen, Su, Ya-Bin, Hong, Chen, Tian, Run-Guo, Su, Lei-Peng, Wang, Yue-Qiao, Li, Yang, Yue, Jun-Jie, Wang, Chao-Jie

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.98 MB

english, 2013

18

Synthesis and antimicrobial profile of N-substituted imidazolium oximes and their monoquaternary salts against multidrug resistant bacteria

Odžak, Renata, Skočibušić, Mirjana, Maravić, Ana

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 456 KB

english, 2013

19

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition

Bernardo, Telma C., Cunha-Oliveira, Teresa, Serafim, Teresa L., Holy, Jon, Krasutsky, Dmytro, Kolomitsyna, Oksana, Krasutsky, Pavel, Moreno, António M., Oliveira, Paulo J.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 2.04 MB

english, 2013

20

Bis-phosphonium salts of pyridoxine: The relationship between structure and antibacterial activity

Pugachev, Mikhail V., Shtyrlin, Nikita V., Sapozhnikov, Sergey V., Sysoeva, Lubov P., Iksanova, Alfiya G., Nikitina, Elena V., Musin, Rashid Z., Lodochnikova, Olga A., Berdnikov, Eugeny A., Shtyrlin,

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.15 MB

english, 2013

21

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifs

Eibl, Christoph, Munoz, Lenka, Tomassoli, Isabelle, Stokes, Clare, Papke, Roger L., Gündisch, Daniela

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 992 KB

english, 2013

22

Synthesis and biochemical evaluation of highly enantiomerically pure (R,R)- and (S,S)-alexidine

Gröst, Corinna, Gräber, Martin, Hell, Michael, Berg, Thorsten

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 2.13 MB

english, 2013

23

Synthesis, structure elucidation and in vitro anticancer activities of novel derivatives of diethyl (2E)-2-[(2E)-(1-arylimidazolidin-2-ylidene)hydrazono]succinate and ethyl (4-oxo-8-aryl-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl)acetate

Sztanke, Małgorzata, Rzymowska, Jolanta, Sztanke, Krzysztof

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 2.53 MB

english, 2013

24

Exploring a potential palonosetron allosteric binding site in the 5-HT3 receptor

Del Cadia, Marta, De Rienzo, Francesca, Weston, David A., Thompson, Andrew J., Menziani, Maria Cristina, Lummis, Sarah C.R.

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 551 KB

english, 2013

25

Graphical contents list

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 2.25 MB

english, 2013

26

Editorial board

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 44 KB

english, 2013

27

Design and synthesis of silicon-containing tubulin polymerization inhibitors: Replacement of the ethylene moiety of combretastatin A-4 with a silicon linker

Nakamura, Masaharu, Kajita, Daisuke, Matsumoto, Yotaro, Hashimoto, Yuichi

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.35 MB

english, 2013

28

Development of fluorinated CB2 receptor agonists for PET studies

Lueg, Corinna, Schepmann, Dirk, Günther, Robert, Brust, Peter, Wünsch, Bernhard

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.16 MB

english, 2013

29

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine–Homoisoflavonoid hybrids

Sun, Yang, Chen, Jianwen, Chen, Xuemin, Huang, Ling, Li, Xingshu

Журнал:

Bioorganic & Medicinal Chemistry

Рік:

2013

Мова:

english

Файл:

PDF, 1.12 MB

english, 2013